View Dr. Subramaniam’s publications in PubMed.

Preprints of Submitted Manuscripts


Uri Nimrod Ramirez Jarquin MS, Neelam Shahani, Yunqing Li, Siddaraju Boregowda,  Srinivasa Subramaniam. Rhes protein transits from neuron to neuron and facilitates mutant huntingtin spreading in the brain. Science Advances. In Press. doi:

Ramirez-Jarquin UN, Sharma M, Zhou W, Shahani N, Subramaniam S. Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease. Proc Natl Acad Sci U S A. 2022;119(5).


Hernandez J, Shahani N, Swarnkar S, and Subramaniam S. Rhes Deletion Prevents Age-Dependent Selective Motor Deficits and Reduces Phosphorylation of S6K in Huntington Disease Hdh150Q(CAG) Knock-In Mice. BioRxiv.

Subramaniam S, and Shahani N. Ribosome Profiling Reveals a Dichotomy Between Ribosome Occupancy of Nuclear-Encoded and Mitochondrial-Encoded OXPHOS mRNA Transcripts in a Striatal Cell Model of Huntington Disease. BioRxiv

Eshraghi M, Karunadharma PP, Blin J, Shahani N, Ricci EP, Michel A, Urban NT, Galli N, Sharma M, Ramirez-Jarquin UN, Florescu K, Hernandez J, Subramaniam S. Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease. Nat Commun. 2021;12(1):1461. Epub 2021/03/07.


Ramirez-Jarquin UN, Shahani N, Pryor W, Usiello A, Subramaniam S. The mammalian target of rapamycin (mTOR) kinase mediates haloperidol-induced cataleptic behavior. Transl Psychiatry. 2020;10(1):336.

Rivera O, Manish S, Shahani N,  Ramírez-Jarquín UN,  Crynen G, Karunadharma P, McManus F, Pierre T, Subramaniam S. Rhes, a Striatal Enriched Protein, Regulates Post-Translational Small-Ubiquitin-like-Modifier (SUMO) Modification of Nuclear Proteins and Alters Gene Expression. BioRxiv. 2020. doi: 10.1101/629667

Sharma M, Rajendrarao S, Shahani N, Ramirez-Jarquin UN, Subramaniam S. Cyclic GMP-AMP synthase promotes the inflammatory and autophagy responses in Huntington disease. Proc Natl Acad Sci U S A. 2020;117(27):

Eshraghi M, Ramirez-Jarquin UN, Shahani N, Nuzzo T, De Rosa A, Swarnkar S, Galli N, Rivera O, Tsaprailis G, Scharager-Tapia C, Crynen G, Li Q, Thiolat ML, Bezard E, Usiello A, Subramaniam S. RasGRP1 is a causal factor in the development of l-DOPA-induced dyskinesia in Parkinson’s disease. Science Advances. 2020;6(18):eaaz7001.

Subramaniam S. Exaggerated mitophagy: a weapon of striatal destruction in the brain? Biochem Soc Trans2020;48(2):709-17.

Subramaniam S. Rhes Tunnels: A Radical New Way of Communication in the Brain’s Striatum? Bioessays. 2020;42(6):e1900231.


Subramaniam S. Selective Neuronal Death in Neurodegenerative Diseases: The Ongoing Mystery. Yale J Biol Med. 2019;92(4):695-705.

Sharma M, Jarquin UNR, Rivera O, Kazantzis M, Eshraghi M, Shahani N, Sharma V, Tapia R, Subramaniam S. Rhes, a striatal-enriched protein, promotes mitophagy via Nix. Proc Natl Acad Sci U S A. 2019;116(47):23760-71.

Sharma M, Subramaniam S. Rhes travels from cell to cell and transports Huntington disease protein via TNT-like protrusion. J Cell Biol. 2019 Jun 3;218(6):1972-1993.(F1000 selection).


Shahani N, Huang WC, Varnum M, Subramaniam S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice. Neurobiology of aging. 2017;50:134-43.


Shahani N, Swarnkar S, Giovinazzo V, Morgenweck J, Bohn L, Scharager-Tapia C, Pascal B, Martinez-Acedo P, Khare K and Subramaniam S. RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network (“Rhesactome”) in the striatum. Science Signaling. 2016;9(454):ra111.doi: 10.1126/scisignal.aaf6670.


Swarnkar S, Chen Y, Pryor WM, Shahani N, Page DT, Subramaniam S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington’s disease. Neurobiol Dis. 2015;82:66-77. Epub 2015/06/07 (F1000 recommendations).

Tyagi R, Shahani N, Gorgen L, Ferretti M, Pryor W, Chen PY, Swarnkar S, Worley PF, Karbstein K, Snyder SH, Subramaniam S. Rheb Inhibits Protein Synthesis by Activating the PERK-eIF2alpha Signaling Cascade. Cell Rep. 2015;10(5):684-9310(5):684-693.

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A. DISC1 regulates trafficking and processing of APP and Abeta generation. Mol Psychiatry. 2015;20(7):874-9.


Pryor WM, Biagioli M, Shahani N, Swarnkar S, Huang WC, Page DT, MacDonald ME, Subramaniam S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease. Science Signaling. 2014;7(349):ra103. Epub 2014/10/30 (F1000selection)

Shahani N, Pryor W, Swarnkar S, Kholodilov N, Thinakaran G, Burke RE, Subramaniam S. Rheb GTPase regulates beta-secretase levels and amyloid beta generation. J Biol Chem. 2014;289(9):5799-808.

Mealer RG, Murray AJ, Shahani N, Subramaniam S*, Snyder SH. Rhes, a striatal-selective protein implicated in Huntington disease, binds beclin-1 and activates autophagy. J Biol Chem. 2014;289(6):3547-54. *Co-correspondence

Narayanan KL, Subramaniam S, Bengston CP, Irmady K, Unsicker K, von Bohlen und Halbach O. Role of transient receptor potential channel 1 (TRPC1) in glutamate-induced cell death in the hippocampal cell line HT22. J Mol Neurosci. 2014;52(3):425-33.


Mealer RG, Subramaniam S, Snyder SH. Rhes deletion is neuroprotective in the 3-nitropropionic acid model of Huntington’s disease. J Neurosci. 2013;33(9):4206-10. 


Subramaniam S*Napolitano F, Mealer RG, Kim S, Errico F, Barrow R, Shahani N, Tyagi R, Snyder SH, Usiello A. Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA-induced dyskinesiaNat Neurosci. 2011;15(2):191-3. Epub 2011/12/20. * Co-first authors (F1000 selection) 


Subramaniam S. and Snyder SH. Huntington’s disease is a disorder of corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum). Neuropharmacology, 2010;60(7-8):1187.

Subramaniam S*, Mealer R*, Sixt KM, Barrow R, Usiello A, Snyder SH.RHES, a physiological regulator of sumoylation, mediates cross-sumoylation among basic sumo enzymes E1 and Ubc9.  J Bio Chem. 2010;285, 20428. *Co-first authors

Subramaniam S and Unsicker K. ERK in cell death: ERK1/2 in neuronal death. FEBS J, 2010;277, 22.


Subramaniam S, Sixt KM, Barrow R and Snyder SH. Rhes, a Striatal Specific Protein, Mediates Mutant- Huntingtin Cytotoxicity. Science, 2009;324, 1327. (F1000 selection).

Alavian KN, Sgado P, Alberi L, Subramaniam S, Simon HH. Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression. Neural Dev. 2009;4:11.


Subramaniam S, Strelau J, Unsicker K. GDNF prevents TGF-beta-induced damage of the plasma membrane in cerebellar granule neurons by suppressing activation of p38-MAPK via the phosphatidylinositol 3- kinase pathway. Cell Tissue Res. 2008;331, 373.

Narayanan KL, Irmady K, Subramaniam S, Unsicker K, von Bohlen und Halbach O. Evidence that TRPC1 is involved in hippocampal glutamate-induced cell death. Neurosci Lett. 2008;446, 117

Subramaniam S and Unsicker K. Extracellular signal-regulated kinase inducer of non-apoptotic neuronal death. Neuroscience 2006;138, 1055-1065.

Shahani N, Subramaniam S, Wolf T, Tackenberg C, Brandt R. Tau aggregation and progressive neuronal degeneration in the absence of changes in spine density and morphology after targeted expression of Alzheimer’s disease-relevant tau constructs in organotypic hippocampal slices. J Neurosci 2006;26, 6103

Shahani N, Subramaniam S, Brandt R.Purification of MINUS: a negative regulator of microtubule nucleation in a variety of organisms. Int. J Biol. Macromol. 2006;39, 15

Subramaniam S, Shahani N, Strelau J, Laliberte C, Brandt R, Kaplan D, Unsicker K. Insulin-like growth factor 1 inhibits extracellular signal-regulated kinase to promote neuronal survival via the phosphatidylinositol 3- kinase/protein kinase A/c-Raf pathway. J Neurosci 2005;25, 2838.Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberte C, Kaplan DR, Unsicker K. ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol. 2004;165, 357.

Subramaniam S, Strelau J*, Unsicker K. Growth differentiation factor-15 prevents low potassium-induced cell death of cerebellar granule neurons by differential regulation of Akt and ERK pathways. J Biol Chem 78, 2003; 8904.

Scholzk MN, Potrovita I, Subramaniam S, Prinz S, Schwaninger M. Glutamate activates NF-kappaB through calpain in neurons. Eur J Neurosci. 2003; 18, 3305.

Schuster N, Bender H, Philippi A, Subramaniam S, Strelau J, Wang Z, Krieglstein K. TGF-beta induces cell death in the oligodendroglial cell line OLI-neu. Glia, 2002;40, 95.